Causal Link between Periodontitis And Kidney Disease
Posted on 5/21/2021 by Greg Kammeyer
The Journal of Periodontology recently published a study that links “periodontal Inflammation” to Renal Function. More than 700 patients were studied at the University Of Birmingham School Of Dentistry in the United Kingdom, by the lead author Praveen Sharma, PhD, BDS, MJDF (RCS Eng), FHEA.

Researchers collated data from dental and biologic data from the Renal Impairment in Secondary Care study using structural equation modeling. The patients with chronic kidney disease were examined using detailed oral and full-body examinations, including blood samples and full-mouth periodontal assessments.

The study showed a 10% increase in gingival inflammation reduces kidney function by 3%. It also showed a 10% reduction in kidney function increases periodontal inflammation by 25%. This effect is mediated by oxidative stress which is an imbalance between the reactive oxygen and the body’s antioxidant capacity, which damages cells. The results indicate that management of periodontal disease may benefit kidney function.

These findings help us to better motivate and manage patients with chronic kidney disease as well as those with periodontal disease. The study leaves me wondering how many other inflammatory sources contribute to chronic organ disease (ie Peri-apical pathology). Certainly it helps care providers and patients justify periodontal therapy and eliminating dental inflammatory sources.
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