New studies show anti-depressant medication is leading to bone loss and dental implant failure…
Selective serotonin reuptake inhibitors (SSRIs) are globally popular antidepressants. But they increase dental implant failure! Recent studies by McGill University and NIH further supported previous evidence about SSRIs having negative effects on bone, particularly in bone mineral density and fracture. Specifically, an article done by the Journal of Dental Research, states there is risk of osseointegrated implant failure. Since osseointegration is influenced by bone metabolism, this study was done to examine the relationship between SSRIs and the risk of failure. The study was conducted on patients treated with dental implants from January 2007 to January 2013. A total of 916 dental implants in 490 patients (94 implants on 51 patients using SSRIs).
After 3 to 67 months of follow-up, 38 dental implants failed and 784 succeeded in the nonusers group, while 10 failed and 84 succeeded in the SSRI-users group. The outcome was that compared with nonusers of SSRIs, SSRI usage was associated with an increased risk of dental implant failure. The failure rate was 4.6% for SSRI nonusers and 10.6% for SSRI users. A secondary outcome was that small implant diameters (less than 4mm) and smoking habits also seemed to increase risk of implant failure. Their findings indicate that treatment with SSRIs is related to an increased failure risk of osseointegrated implants, which might suggest a more cautious surgical treatment planning for SSRI users. This may also affect other bone healing with other surgical procedures.
SSRI Anti-depressants Zoloft (Sertraline) Prozac (Fluoxetine) Celexa (Citalopram) Lexapro (Escitalopram) Paxil Pexeva (Paroxetine) Luvox (Fluvoxamine)